Peripheral Blood Lymphocyte Subset Abnormalities in Antiphospholipid Syndrome
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Review Article
Javier Carbone, Carmen Chean, Nallibe Lanio, Antonio Gallego, Nadia del Pozo and Elizabeth Sarmiento
Affiliations: Clinical Immunology Department, University Hospital Gregorio Marañon
ABSTRACT
Miscarriage and thrombosis are important causes of morbidity and mortality in patients with the antiphospholipid (Hughes) syndrome. However, the precise mechanism responsible for these complications remains unclear. Among the different immunity‐related components that could be implicated in the pathogenesis of this systemic autoimmune disease, immunophenotypic abnormalities in peripheral blood lymphocytes have rarely been sought. We review studies that have been designed to assess functionally distinct T, B, and natural killer lymphocyte subsets in patients with antiphospholipid syndrome.
Keywords: lymphocyte subsets, antiphospholipid syndrome, CD19, CD4, CD8, NK cell, flow cytometry
Correspondence: Javier Carbone, Clinical Immunology Department, University Hospital Gregorio Marañon, Dr. Esquerdo 46, 28007 Madrid, Spain. Tel: (34)‐91 ‐4265180; Fax: (34)‐91‐5866698; e‐mail: carbone@teleline.es
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